Lipotris™ – smoother movement for osteoarthritis
Lipotris™ is a specialised gel that your doctor injects directly into the affected joint. The gel forms a smooth protective layer over the cartilage, allowing the joint surfaces to glide and roll past each other more easily, making movement feel more comfortable. The gel also improves the environment inside the joint from within: irritation decreases, which can reduce pain and inflammation. This effect is not short-lived — many patients notice the result of a single treatment for up to two years.
How does Lipotris™ work?
With osteoarthritis, the quality of the joint fluid gradually deteriorates due to the inflammatory reactions that occur in the joint. As a result, the fluid lubricates and nourishes the joint less effectively, causing further damage to the cartilage. Lipotris™ intervenes at two points.
1. Less friction = smoother movement
The gel spreads over the cartilage and forms a protective layer there. The joint glides and rolls more easily again, and the cartilage is subjected to less load with every step. That reduced load is also beneficial in the longer term: the less mechanical wear, the slower the osteoarthritis process progresses.
2. Supporting the joint from within
Lipotris™ contains hyaluronic acid with a high molecular weight. It is precisely this form that binds well to CD44, a natural receptor on the cells in your joint. Through this binding, Lipotris™ helps with:
- reducing inflammation
- stimulating the repair of joint cells
- improving the quality of the joint fluid
So Lipotris™ doesn't just work mechanically as a lubricant — it also supports the biology of the joint itself.
What's inside Lipotris™?
Each pre-filled syringe contains a carefully composed formula for maximum, long-lasting effect.
Liposomes: from sliding to rolling
Alongside hyaluronic acid, Lipotris™ also contains liposomes — microscopically small, round fat spheres. Inside the joint they act like tiny ball bearings: the layer between the joint surfaces doesn't just slide, it also rolls. This lets the bone surfaces move past each other even more easily, with virtually no friction — up to 16% smoother than with hyaluronic acid alone.
Why does Lipotris™ last so long?
Most hyaluronic acid preparations are broken down by the body within two to six weeks. Lipotris™ is built differently and remains present in the joint for up to 100 days — more than three months.
This is thanks to the Lipotris Assembly Process (LAP™): a manufacturing method that makes the gel extra stable and protects it against rapid breakdown. Lipotris™ also binds to the CD44 protein in your joint, which plays a role in repair and in reducing inflammation. This means the gel not only stays in place longer, but also supports the joint's natural balance.
The result: patients can benefit from a single treatment course for 6 to 24 months.
Presence in the joint
What will you notice?
Many patients experience:
How many injections are needed?
A complete Lipotris™ treatment consists of three injections of 2 ml each. This protocol has been carefully designed for an optimal, long-lasting effect. Your healthcare provider will discuss the ideal interval between injections with you, tailored to your personal situation.
Three injections, spread over time
One injection per visit, with an interval determined by your healthcare provider.
Why choose Lipotris™?
Clinical evidence
Clinical data show that a treatment schedule of three consecutive intra-articular injections with Lipotris™, with an interval of 7 days, leads to a significant reduction in osteoarthritis-related symptoms. A clinical effect is observable from around 14 days after the first injection and continues for at least 6 months.
An extensive follow-up was carried out after 2 years to document long-term clinical outcomes. At 2 years, the WOMAC score still showed an improvement of between 10–15 points, and the VAS scale between 2–3 points. So two years after treatment, a significant improvement is still visible.
Watch how Lipotris™ works
Safety and manufacturing
Lipotris™ has an excellent safety profile. This is because the product is manufactured with great care and cleanliness.
- The hyaluronic acid is produced through controlled bacterial fermentation, a safe and widely used method.
- The liposomes are fully synthetic, so they are not derived from animals or plants.
- Manufacturing takes place via the Lipotris Assembly Process (LAP™), which ensures a consistent quality that is highly resistant to breakdown in the joint.
- Thanks to this careful manufacturing process, the risk of unwanted reactions in the joint is very low.
What is Lipotris™ used for?
Lipotris™ is intended for people with osteoarthritis who experience pain, stiffness, and difficulty moving. The treatment helps the joint move more smoothly, reduces pain, and improves the quality of everyday movement.
Each treatment in brief
Three injections of 2 ml, spread over multiple visits.
The injection is always administered by a medical professional.
Summary
Lipotris™ is an innovative joint injection that actively improves movement in an osteoarthritic joint. The gel forms a protective, low-friction layer, reduces friction, and supports the joint from within. Many patients experience rapid relief of pain and stiffness, better movement quality, and a long-lasting effect — all with a very high safety profile.
Scientific references
- Petelska AD, Kazimierska-Drobny K, Janicka K, Majewski T, Urbaniak W. Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study. Coatings 2019;9(4):264. doi.org/10.3390/coatings9040264
- Altman RD, Bedi A, Karlsson J, Sancheti P, Schemitsch E. Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. Am J Sports Med. 2016;44(8):2158-2165. doi:10.1177/0363546515609599
- Bakowski P, Madej W. Liposomal intra-articular gel provides components for ultra-low friction in the synovial joint, thus improving clinical and functional outcomes of patients with osteoarthritis. Osteoarthritis and Cartilage 2024;32:S45-S46.
- Lin W, Mashiah R, Seror J, Kadar A, Dolkart O, Pritsch T, Goldberg R, Klein J. Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction. Acta Biomater. 2019;83:314-321. doi: 10.1016/j.actbio.2018.11.015
- Greene GW, Banquy X, Lee DW, Lowrey DD, Yu J, Israelachvili JN. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A. 2011;108(13):5255-9. doi: 10.1073/pnas.1101002108
- Seidman AJ, Limaiem F. Synovial Fluid Analysis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
- Jahn S, Seror J, Klein J. Lubrication of Articular Cartilage. Annu Rev Biomed Eng. 2016;18:235-258. doi.org/10.1146/annurev-bioeng-081514-123305
- Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci 2023;24(7):6405. doi: 10.3390/ijms24076405
- NOV Standpunt Hyaluronzuur-injecties bij artrose van de knie. Version 2.0; December 2019.
- Webner D, Huang Y, Hummer CD 3rd. Intraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others? Cartilage. 2021;13(1_suppl):1619S-1636S. PMID: 34044600
- Ferkel E, Manjoo A, Martins D, Bhandari M, Sethi P, Nicholls M. Intra-articular Hyaluronic Acid Treatments for Knee Osteoarthritis: A Systematic Review of Product Properties. Cartilage. 2023;14(4):424-432. PMID: 37314014
- Brophy RH, Fillingham YA. AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition. J Am Acad Orthop Surg. 2022;30(9):e721-e729. PMID: 35383651
- Jawanda H, Khan ZA, Warrier AA, et al. Platelet-Rich Plasma, Bone Marrow Aspirate Concentrate, and Hyaluronic Acid Injections Outperform Corticosteroids in Pain and Function Scores at a Minimum of 6 Months as Intra-Articular Injections for Knee Osteoarthritis. Arthroscopy. 2024;40(5):1623-1636.e1. PMID: 38331363
- Familiari F, Ammendolia A, Rupp MC, et al. Efficacy of intra-articular injections of hyaluronic acid in patients with glenohumeral joint osteoarthritis: A systematic review and meta-analysis. J Orthop Res. 2023;41(11):2345-2358. PMID: 37314198
- Bensa A, Bianco Prevot L, Moraca G, et al. Corticosteroids, hyaluronic acid, platelet-rich plasma, and cell-based therapies for knee osteoarthritis. Expert Opin Biol Ther. 2025;25(3):309-318. PMID: 40028854
- Lippi L, Ferrillo M, Turco A, et al. Multidisciplinary Rehabilitation after Hyaluronic Acid Injections for Elderly with Knee, Hip, Shoulder, and Temporomandibular Joint Osteoarthritis. Medicina (Kaunas). 2023;59(11):2047. PMID: 38004096
- Falkowski K, Bączkowicz D. Single Injection of Highly Concentrated Hyaluronic Acid Provides Improvement of Knee Joint Arthrokinematic Motion and Clinical Outcomes in Patients with Osteoarthritis. J Clin Med. 2025;14:3557. doi.org/10.3390/jcm14103557
- Troncoso JB, Fernandez JR, et al. Different hyaluronan concentration determinate distinctive physicochemical and biological properties of the intra-articular gel but does not affect satisfactory clinical outcome. JOREP 2025;4:100445. doi.org/10.1016/j.jorep.2024.100445
- Altman R, et al. Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review. Cartilage. 2019. PMID: 29429372
- Hussain S, Rather H, Qayoom A. Efficacy, tolerability and adverse events of single-shot intra-articular hyaluronic acid injection in knee osteoarthritis. JMS SKIMS 2015;18(2):128-133.
- Mohammed AA, Niamah AK. Identification and antioxidant activity of hyaluronic acid extracted from local isolates of Streptococcus thermophilus. Materials Today: Proceedings. 2022;60:1523-1529.
- Bąkowski P, Bełdowski P, Kaszyński J, Bąkowska-Żywicka KG, Krakowski P, Piontek T, Marín Fermín T. Liposomal composite gel for knee osteoarthritis: mechanical and physicochemical properties assessment and clinical outcomes of a single-arm prospective study. J Cartilage Jt Preserv. 2026;100321. doi.org/10.1016/j.jcjp.2026.100321
Questions or more information?
Our team is ready to answer all your questions about Lipotris™. Are you a healthcare provider? Then you can order directly from Supportho Medical.